OF THE NEW DRUG PROTECOR UPON PERORAL ADMINISTRATION IN RABBITS AND BEAGLE DOGS

A new high-performance liquid chromatographic method with ultraviolet detection has been used to determine the levels of the new cardiotropic drug protecor in the blood of animals (chincilla rabbits, 2.2 0.2 kg; and beagle dogs, 10 0.5 kg). The parameters of protecor pharmacokinetics and bioavailability upon peroral administration of protecor tablets have been determined. Rabbits showed effective absorption of the drug uupon peroral administration in a single dose (100 mgkg) with a peak concentration in the plasma (Cmax =4 1gmL) reached within Tmax = 3 h followed by rapid removal of the drug from the organism with a half-elimination time T12 = 1.71 h. Peroral administration of protecor in a single dose (50 mgkg) in beagle dogs was characterized by Cmax = 34.6 gmL, Tmax =3h , andT12 = 0.75 h. The bioavailability of protecor upon peroral administration was estimated at 90% (rabbits) and 80.7% (beagle dogs).