2016Emerging infectious diseasesOpen access

Novel Reassortant Clade 2.3.4.4 Avian Influenza A(H5N8) Virus in Wild Aquatic Birds, Russia, 2016

Dong‐Hun Lee, Kirill Sharshov, David E. Swayne, Olga Kurskaya, Ivan Sobolev, Мarsel R. Kabilov, А. Yu. Alekseev, Victor Irza, А. М. Шестопалов

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Abstract

Because of the social and economic relationships between China and Gabon, the travels of asymptomatic CPE carriers from China to Gabon can be expected to have facilitated the spread of CPE in Gabon.Several multidrug-resistant clones of K. pneumoniae, including sequence type 307 (10), have been recognized as having emerging epidemic potential worldwide.The genome analysis of the 3 bla NDM-7producing K. pneumoniae isolates from Gabon revealed clonal isolates (2 and 5 single-nucleotide polymorphisms between them) of sequence type 307.This result suggests an uncontrolled spread in the hospital intensive care unit.This description of bla NDM-7 in Africa highlights the international dissemination of carbapenemase determinants and the combination of 2 aggravating factors, resulting in an alarming situation: the identification of bla NDM-7 within a transposon element on a conjugative plasmid with a potentially very high level of transmissibility, and the implication of the presence of K. pneumoniae, a pathogen with a high potential to persist and disperse in the hospital environment.Urgent measures are required, including the rational use of antimicrobial drugs, public education on the importance of hygiene, and diligent surveillance to control the spread of these multidrug-resistant organisms in the hospital setting.

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Because of the social and economic relationships between China and Gabon, the travels of asymptomatic CPE carriers from China to Gabon can be expected to have facilitated the spread of CPE in Gabon.Several multidrug-resistant clones of K. pneumoniae, including sequence type 307 (10), have been recognized as having emerging epidemic potential worldwide.The genome analysis of the 3 bla NDM-7producing K. pneumoniae isolates from Gabon revealed clonal isolates (2 and 5 single-nucleotide polymorphisms between them) of sequence type 307.This result suggests an uncontrolled spread in the hospital intensive care unit.This description of bla NDM-7 in Africa highlights the international dissemination of carbapenemase determinants and the combination of 2 aggravating factors, resulting in an alarming situation: the identification of bla NDM-7 within a transposon element on a conjugative plasmid with a potentially very high level of transmissibility, and the implication of the presence of K. pneumoniae, a pathogen with a high potential to persist and disperse in the hospital environment.Urgent measures are required, including the rational use of antimicrobial drugs, public education on the importance of hygiene, and diligent surveillance to control the spread of these multidrug-resistant organisms in the hospital setting.

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Available abstract

Because of the social and economic relationships between China and Gabon, the travels of asymptomatic CPE carriers from China to Gabon can be expected to have facilitated the spread of CPE in Gabon.Several multidrug-resistant clones of K. pneumoniae, including sequence type 307 (10), have been recognized as having emerging epidemic potential worldwide.The genome analysis of the 3 bla NDM-7producing K. pneumoniae isolates from Gabon revealed clonal isolates (2 and 5 single-nucleotide polymorphisms between them) of sequence type 307.This result suggests an uncontrolled spread in the hospital intensive care unit.This description of bla NDM-7 in Africa highlights the international dissemination of carbapenemase determinants and the combination of 2 aggravating factors, resulting in an alarming situation: the identification of bla NDM-7 within a transposon element on a conjugative plasmid with a potentially very high level of transmissibility, and the implication of the presence of K. pneumoniae, a pathogen with a high potential to persist and disperse in the hospital environment.Urgent measures are required, including the rational use of antimicrobial drugs, public education on the importance of hygiene, and diligent surveillance to control the spread of these multidrug-resistant organisms in the hospital setting.

Key concepts: Reassortment, Influenza A virus subtype H5N1, Waterfowl, Clade, Biology, Virology, Influenza A virus, Virus

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Novel Reassortant Clade 2.3.4.4 Avian Influenza A(H5N8) Virus in Wild Aquatic Birds, Russia, 2016 — Research Paper | ScholarLens