Neuroleptic Malignant Syndrome and Dantrolene. A Case Report
Gustavo Cruz, Sergio Jaramillo, Beatríz Sánchez-Hernández, Fredy Ariza, Angy Cruz, Fundación Valle de Lili, Cruz Suárez
Abstract
Gustavo Cruz, Sergio Jaramillo, Beatríz Sánchez-Hernández, Fredy Ariza, Angy Cruz, Fundación Valle de Lili, Cruz Suárez
Abstract
Neuroleptic malignant syndrome is a rare condition; manifestations include severe autonomic dysfunction, hyperthermia and muscle rigidity, among others. This may occur in response to drugs that interact with dopaminergic pathways. Diagnosis of this syndrome is mainly clinical since there is no specific laboratory test for this condition and it has a high mortality rate given its multiorgan involvement. This is a case report of a patient who developed neuroleptic malignant syndrome that was managed with supportive therapy and dantrolene.
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Neuroleptic malignant syndrome is a rare condition; manifestations include severe autonomic dysfunction, hyperthermia and muscle rigidity, among others. This may occur in response to drugs that interact with dopaminergic pathways. Diagnosis of this syndrome is mainly clinical since there is no specific laboratory test for this condition and it has a high mortality rate given its multiorgan involvement. This is a case report of a patient who developed neuroleptic malignant syndrome that was managed with supportive therapy and dantrolene.
Key concepts: Neuroleptic malignant syndrome, Dantrolene, Muscle Rigidity, Malignant hyperthermia, Medicine, Rhabdomyolysis, Anesthesia, Dantrolene Sodium