Epidermodysplasia Verruciformis Associated with Scleroderma

Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by flat warts or scaling macules resembling pityriasis versicolor. We describe a 30-year-old man with EV associated with scleroderma. The lesions, persisting for more than 10 years, consisted of widespread planar warts on the backs of the hands and wrists, and reddish-brown macules on the trunk, neck and face. He also presented with sclerodermatous skin changes on the lower extremities last 2 years. There are 2 case reports about autoimmune diseases including vitiligo and autoimmune polyendocrinopathy associated with EV in the literature. Though scleroderma may coexist with other autoimmune diseases, its presentation with EV has not yet been described. It is concluded that patients with EV should be carefully evaluated for the occurrence of sclerodermatous skin changes. The appearance of both diseases in our patient may be a coincidental association but anti-HPV antibodies may also contribute to this co-existence.