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2016•Asian Journal of Research in ChemistryOpen access

Validated UV-Spectroscopic estimation of Simvastatin Concentration in Bulk and Dosage form

Pramod Nanasaheb Katkade, R.B. Saudagar

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Abstract

A simple, accurate, precise, and sensitive a highly selective ultra violet spectrophotometric method has been developed for the estimation of drug in bulk and dosage form. It shows maximum absorbance at 238nm. The Beer-Lambert's law was obeyed in the concentration range of 5–35μg/ml. The linear regression analysis data for calibration plots showed good linear relationship and obtain correlation factor for Simvastatin. The percentage recovery was found to be within range. Thus method was successfully applied for routine analysis of Simvastatin in bulk drug and dosage form.

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A simple, accurate, precise, and sensitive a highly selective ultra violet spectrophotometric method has been developed for the estimation of drug in bulk and dosage form. It shows maximum absorbance at 238nm. The Beer-Lambert's law was obeyed in the concentration range of 5–35μg/ml. The linear regression analysis data for calibration plots showed good linear relationship and obtain correlation factor for Simvastatin. The percentage recovery was found to be within range. Thus method was successfully applied for routine analysis of Simvastatin in bulk drug and dosage form.

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Available abstract

A simple, accurate, precise, and sensitive a highly selective ultra violet spectrophotometric method has been developed for the estimation of drug in bulk and dosage form. It shows maximum absorbance at 238nm. The Beer-Lambert's law was obeyed in the concentration range of 5–35μg/ml. The linear regression analysis data for calibration plots showed good linear relationship and obtain correlation factor for Simvastatin. The percentage recovery was found to be within range. Thus method was successfully applied for routine analysis of Simvastatin in bulk drug and dosage form.

Key concepts: Simvastatin, Chemistry, Dosage form, Chromatography, Pharmacology, Medicine

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