ScholarLens Back to search
2016•Anais do Congresso de Iniciação Científica da UnicampOpen access

Study of the relationship between the proteins Nucleophosmin-1 and Nucleolin and different S6Ks isoforms

Fernando Riback Silva, Fernando Moreira Simabuco, Isadora Carolina Betim Pavan, Ana Paula Morelli

Open full text 0 citations

Abstract

The mTOR signaling pathway has been related to several diseases and metabolic disorders in humans, including obesity, diabetes and various types of cancer.The S6Ks proteins have shown important roles in the signaling of mTOR, acting as effectors of this pathway, but there are still open questions, such as their functional differences and interacting proteins.The aim of this study was to investigate the possible relationship between the proteins Nucleophosmin1 (NPM1) and Nucleolin (NCL), involved with cell proliferation, biogeneses of ribossomes and protein syntesis, and the S6Ks.

Open-access reader

About this research paper

What this paper is about

The mTOR signaling pathway has been related to several diseases and metabolic disorders in humans, including obesity, diabetes and various types of cancer.The S6Ks proteins have shown important roles in the signaling of mTOR, acting as effectors of this pathway, but there are still open questions, such as their functional differences and interacting proteins.The aim of this study was to investigate the possible relationship between the proteins Nucleophosmin1 (NPM1) and Nucleolin (NCL), involved with cell proliferation, biogeneses of ribossomes and protein syntesis, and the S6Ks.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

The mTOR signaling pathway has been related to several diseases and metabolic disorders in humans, including obesity, diabetes and various types of cancer.The S6Ks proteins have shown important roles in the signaling of mTOR, acting as effectors of this pathway, but there are still open questions, such as their functional differences and interacting proteins.The aim of this study was to investigate the possible relationship between the proteins Nucleophosmin1 (NPM1) and Nucleolin (NCL), involved with cell proliferation, biogeneses of ribossomes and protein syntesis, and the S6Ks.

Key concepts: Nucleophosmin, Nucleolin, Gene isoform, Focus (optics), Cell biology, Computational biology, Chemistry, Computer science

Related papers

Related paper 1Related paper 2
Back to paper searchBrowse research topicsOriginal source
Study of the relationship between the proteins Nucleophosmin-1 and Nucleolin and different S6Ks isoforms — Research Paper | ScholarLens