An unusual presentation of Stewart-Treves syndrome on the lower extremity

Cutaneous angiosarcoma is a rare and aggressive malignant tumor derived from endothelial cells, which can develop de novo, in irradiated skin, or in areas of chronic lymphedema. Stewart-Treves syndrome describes the association of cutaneous angiosarcoma arising in the setting of lymphedema. This syndrome was first reported in 1948 by Drs Fred Stewart and Norman Treves, who noted 6 cases of lymphangiosarcoma that developed several years after a Halstead radical mastectomy.1