Clinical study of thalidomide combined with ondansetron in the prevention of nausea and vomiting in lung cancer patients with chemotherapy

Objective:To observe the effectiveness and safety of combination of thalidomide and ondansetronin to prevent the nausea and vomiting in lung cancer patients received containing two drug regimen of cisplatin chemothera-py.Methods:From February 2014 to February 2016,60 lung cancer patients were randomly divided into experimental group(30 cases)and control group(30 cases).All the patients were scheduled to receive containing cisplatin 25mg/m2 d1 ~3 dual regimen chemotherapy.Patients in the control group were injected ondansetron 8mg qd d1 ~3 30min before chemotherapy.In the experimental group,patients administed thalidomide tablets 100mg oral d1 ~5 extra.Results:The effective rate of acute nausea control in the experimental group and the control group was 90% vs 80%,the complete remission rate was 73 % vs 67 %,the difference was not statistically significant(P >0.05).In the experimental group and control group,the efficiency of delayed nausea control in 2 ~5 days was 87% vs 53%(P =0.011),80%vs 47%(P =0.016),80% vs 50%(P =0.030),87% vs 74%(P =0.331).The complete remission rate of delayed nausea control in 2 ~5 days was 67% vs 37%(P =0.039),57% vs 27%(P =0.036),60% vs 23%(P =0.009), 67% vs 40%(P =0.070).The effective rate of acute vomiting control in the experimental group and the control group was 93% vs 90%,the complete remission rate was 84% vs 77%,the difference was not statistically significant (P >0.05).In the experimental group and control group,the efficiency of delayed vomiting control in the 2 ~5 days was 90% vs 73%(P =0.182),83% vs 70%(P =0.360),87% vs 73%(P =0.333),94% vs 80%(P =0.255). The complete remission rate of delayed vomoting control in 2 ~5 days was 76% vs 46%(P =0.034),66% vs 33%(P =0.020),70% vs 40%(P =0.038),73% vs 50%(P =0.110).The adverse reactions in both groups were tol-erable,sedation,drowsiness,fatigue,constipation,headache and skin rash were not statistically significant(P >0.05). Conclusion:The combination of thalidomide and ondansetron can effectively prevent delayed nausea and vomiting of lung cancer patients those were administraited with double drug chemotherapy contain cisplatin,meanwhihe did not in-crease adverse reaction.Thalidomide may be an alternative antiemetic agent.