2010•Repository KITopen (Karlsruhe Institute of Technology)Open access
Involvement of Tspan8 in exosome assembly and target cell selection
Sanyukta Rana
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Abstract
Exosomes are the most important intercellular communicators. Tetraspanins/their complexes are suggested to be important in exosomal target cell selection. I showed: changes in Tetraspanin8 associations created from internalization persist upto exosomes and, differences in tetraspanin-complexes on exosomes allow for target cell selectivity.Based on the tetraspanin-complex on exosomes, predictions on potential target cells might be possible, allowing tailored exosome generation for drug delivery.