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Bioreduction of α-haloacetophenones by Rhodotorula glutinis and Geotrichum candidum

Lucidio Cristovão Fardelone, J. Augusto R. Rodrigues, Paulo J. S. Moran

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Abstract

Enantioselective reductions with enantiocomplementarity of α-haloacetophenones by Rhodotorula glutinis CCT 2182 and Geotrichum candidum CCT 1205 afforded the corresponding (R)-and (S)-halohydrins (halo = Cl, Br and I), respectively, in high chemical yields (89-99%) and enantiomeric excesses (92-99%).These halohydrins are potential chiral building blocks for the stereoselective syntheses of valuable compounds.

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Enantioselective reductions with enantiocomplementarity of α-haloacetophenones by Rhodotorula glutinis CCT 2182 and Geotrichum candidum CCT 1205 afforded the corresponding (R)-and (S)-halohydrins (halo = Cl, Br and I), respectively, in high chemical yields (89-99%) and enantiomeric excesses (92-99%).These halohydrins are potential chiral building blocks for the stereoselective syntheses of valuable compounds.

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Available abstract

Enantioselective reductions with enantiocomplementarity of α-haloacetophenones by Rhodotorula glutinis CCT 2182 and Geotrichum candidum CCT 1205 afforded the corresponding (R)-and (S)-halohydrins (halo = Cl, Br and I), respectively, in high chemical yields (89-99%) and enantiomeric excesses (92-99%).These halohydrins are potential chiral building blocks for the stereoselective syntheses of valuable compounds.

Key concepts: Geotrichum, Chemistry, Rhodotorula, Enantioselective synthesis, Enantiomer, Stereoselectivity, Organic chemistry, Stereochemistry

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