2016•HaematologicaOpen access

Absence of CALR mutations in JAK2 -negative polycythemia

Aurélie Chauveau, Olivier Nibourel, Sylvie Tondeur, Damien Luque Paz, Olivier Mansier, Franciane Paul, Mathieu Wémeau, Claude Preudhomme, Éric Lippert, Valérie Ugo

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Abstract

Polycythemia vera (PV) is a myeloproliferative neoplasm (MPN) responsible for increased hematopoiesis, mainly affecting the erythroid lineage. The diagnosis of PV has been simplified enormously by the description of JAK2 mutations, affecting the canonical V617 in exon 14 in more than 95% of cases,

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Key concepts: Polycythemia vera, Myeloproliferative neoplasm, Myelofibrosis, Mutation, Exon, Myeloproliferative Disorders, Haematopoiesis, Lineage (genetic)