Effects of Pre-inhalation of Salbutamol on Cough Reflex Induced by Sufentanil

Purposes: This study was designed to evaluate the effect of pre-inhalation of salbutamol aerosol(200μg) and injection speed on sufentanil-induced cough.Methods: 160 patients aged 25-62yr, ASA Ⅰ-Ⅱ, scheduled for various elective surgical procedures under general anesthesia were randomly allocated into four groups of 40 each.Group Ⅱ, Ⅳ served as control received saline aerosol, and Group Ⅰ, Ⅲ received a preinhalation of one metered aerosol puff of salbutamol(200μg) 10min prior to intravenous injection of sufentanil.Sufentanil 0.5μg/kg was administered within 3s in GroupⅠ, Ⅱ, or over 30s in Group Ⅲ, Ⅳ.The concentration of sufentanil was 10μg/ml.The incidences and severity of cough that occurred within 1 min after the injection of sufentanil were recorded, the HR and SBP at pre-anesthetic(T1), 5 minutes after inhalation(T2) , and 1 minute after injecting sufentanil (T3) were also recorded.Results: The incidence of cough in GroupⅠ, Ⅳ(10%,12.5%)were less than Group Ⅱ(37.5%) (p<0.05);The incidence of cough in Group Ⅲ(2.5%) was significantly lower Group Ⅱ (p<0.01).The highest non-invasive blood (NIBP) and heart rate (HR) were at T3 timepoint in Group Ⅱ(p<0.05).Conclusions: The pre-inhalation of salbutamol(200μg) combined with a prolonged injection time significantly reduced the incidence of sufentanil-induced.