2000•Journal watchRequires access

New Flu Drugs: Modest Benefits at Best

A Zuger

Abstract

Two new prescription drugs for treating influenza were approved by the FDA in 1999 despite some controversy over their usefulness. Zanamivir (Relenza) and oseltamivir (Tamiflu) both act by inhibiting the viral enzyme neuraminidase. Unlike the older flu drugs amantadine and rimantadine, the new drugs have few substantial side effects and are active against influenza B as well as influenza A. Zanamivir is administered by inhalation. When patients with …

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Key concepts: Zanamivir, Rimantadine, Amantadine, Oseltamivir, Medicine, Neuraminidase inhibitor, Neuraminidase, Pharmacology