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[Effect of acitretin and methotrexate on treatment of severe plaque psoriasis].

Panpan Liu, Yehong Kuang, Jianglin Zhang, Jie Li, Juan Su, Xiang Chen, Wu Zhu

Open publisher page 2 citations

Abstract

OBJECTIVE: To evaluate effects of acitretin and methotrexate on treatment of severe plaque psoriasis. METHODS: A total of 54 patients were treated with either acitretin (32 patients; 30 mg per day) or methotrexate (22 patients; 15 mg per week) for 8 weeks. The therapeutic effects of the two drugs were evaluated according to the psoriasis area and severity index (PASI). RESULTS: After 8 weeks of treatment, the score of PASI decreased in both the acitretin group and the methotrexate group (P<0.001). However, there was no significant differences neither in the percentage reduction in the PASI score nor in PASI response rate between the two groups (P>0.05). CONCLUSION: Acitretin and methotrexate exert similar therapeutic effect in severe plaque psoriasis.

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What this paper is about

OBJECTIVE: To evaluate effects of acitretin and methotrexate on treatment of severe plaque psoriasis. METHODS: A total of 54 patients were treated with either acitretin (32 patients; 30 mg per day) or methotrexate (22 patients; 15 mg per week) for 8 weeks. The therapeutic effects of the two drugs were evaluated according to the psoriasis area and severity index (PASI). RESULTS: After 8 weeks of treatment, the score of PASI decreased in both the acitretin group and the methotrexate group (P<0.001). However, there was no significant differences neither in the percentage reduction in the PASI score nor in PASI response rate between the two groups (P>0.05). CONCLUSION: Acitretin and methotrexate exert similar therapeutic effect in severe plaque psoriasis.

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Available abstract

OBJECTIVE: To evaluate effects of acitretin and methotrexate on treatment of severe plaque psoriasis. METHODS: A total of 54 patients were treated with either acitretin (32 patients; 30 mg per day) or methotrexate (22 patients; 15 mg per week) for 8 weeks. The therapeutic effects of the two drugs were evaluated according to the psoriasis area and severity index (PASI). RESULTS: After 8 weeks of treatment, the score of PASI decreased in both the acitretin group and the methotrexate group (P<0.001). However, there was no significant differences neither in the percentage reduction in the PASI score nor in PASI response rate between the two groups (P>0.05). CONCLUSION: Acitretin and methotrexate exert similar therapeutic effect in severe plaque psoriasis.

Key concepts: Acitretin, Psoriasis Area and Severity Index, Psoriasis, Methotrexate, Plaque psoriasis, Medicine, Gastroenterology, Dermatology

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[Effect of acitretin and methotrexate on treatment of severe plaque psoriasis]. — Research Paper | ScholarLens