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Beyond Patched and Sonic Hedgehog to Smoothened
J Bolognia
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Abstract
Smoothened (SMO) is a protein that resides within the plasma membrane of cells, including keratinocytes. When activated, SMO triggers a cascade of cellular events that can result in tumor formation and altered embryonic development. The activity of SMO is regulated by an associated membrane receptor known as patched (PTCH), the protein product of the patched gene. The normal …