Antidiarrheal Activity of Three Medicinal Plants in Swiss Albino Mice

Background: Different parts of Allamanda neriifolia (AN), Crinum latifolium (CL), and Bruguiera cylindrica (BC) are used in folk medicine to treat diarrhea.Therefore, the aim of this study was to investigate and compare possible antidiarrheal activity of the crude extracts from barks, stems, and roots of AL, CL, and BC in Swiss albino mice.Methods: Antidiarrheal activities of extracts were evaluated at three doses (100 mg/kg, 200 mg/kg and 400 mg/kg) and compared with Loperamide in a castor oil-induced diarrhea and charcoal meal test model in the Swiss albino mice. Results:The aqueous extract of CL and BC administered at doses of 100, 200 and 400 mg/kg showed 0%, 24.5%, 62.26% and 5.66%, 37.11%, and 62.26% diarrhea inhibition, respectively.This reduction in diarrheal episodes is significant, and maximum effect was observed at the dose of 400 mg/kg similarly in the alcohol extracts of both CL and BC.AN administered at the dose of 100, 200 and 400 mg/kg showed 55.97%, 74.84% and 74.84% diarrhea inhibition, respectively.The aqueous extracts of AN, CL and BC were able to increase the percentage inhibition of the charcoal meal movement. Conclusion:The antidiarrheal effect of the AN extract, in contrast to CL and BC, against the castor oil-induced diarrhea model prove its efficacy in an extensive range of diarrheal conditions.(IntJ Biomed.2016;6(3):233-236.).