S i M i S no RNA: Collection of siRNA, miRNA, and snoRNA database for RNA interference / S i M i S no RNA: RNA Interferansı için siRNA, miRNA ve snoRNA veritabanında depolanan siRNA, miRNA, and snoRNA koleksiyonları

Abstract Objective: The discovery of sequence specific gene silencing which occurs due to the presence of double- stranded RNAs has considerable impact on biology, revealing an unknown level of regulation of gene expression. This process is known as RNA interference (RNAi) or RNA silencing in which RNA molecules inhibit gene expression, typically by causing the destruction of specific mRNA molecule. Two types of small RNA molecules-small interfering RNA (siRNA) and microRNA (miRNA) are central to RNA interference. Therefore, S i M i S no RNA database has been developed to focus on the efficient storage of RNA interferences or small RNA sequences and qualitative analysis of its structures across variety of organisms. Methods: S i M i S no RNA database is developed using WAMP server which implements Apache, MySQL, and PHPas principal components. Results: A flexible web-based search engine is developed to obtain fast access to specific small RNA sequence information. Conclusion: BLAST search analysis within S i M i S no RNA enables users to compare their own query sequence data with S i M i S no RNA database to retrieve related information. To facilitate data consistency, publicly available information from NCBI has been integratedinto database that can be conveniently used for research on the experimental and molecular biology.