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2016•Unpublished venueRequires access

CARCINOSARCOMA EX PLEOMORPHIC ADENOMA OF THE PAROTID GLAND: A CASE REPORT

Chun-Chieh Wu, Ying‐Hsiang Chou, Yuting Wang, Yueh‐Chun Lee, Hsien‐Chun Tseng

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Abstract

Pleomorphic adenoma of the parotid gland is the most common tumor of the salivary glands. Although very rare, this tumor can undergo malignant transformation, resulting in carcinosarcoma ex pleomorphic adenoma, which possesses the characteristics of both carcinoma and sarcoma. In the literature, the number of such cases is very low and the treatment outcomes are varied. Surgery remains the primary local treatment. Radiotherapy may be added to enhance local-regional control. Here, we present a 45-year-old male who underwent surgical removal of pleomorphic adenoma of the right parotid gland twice. He was eventually diagnosed with carcinosarcoma ex pleomorphic adenoma. Treatment consisted of superficial parotidectomy and adjuvant concurrent chemoradiation with weekly cisplatin and a radiation dose of 66 Gy. After 30 weeks of follow-up, no disease recurrence or distant metastasis was observed.

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What this paper is about

Pleomorphic adenoma of the parotid gland is the most common tumor of the salivary glands. Although very rare, this tumor can undergo malignant transformation, resulting in carcinosarcoma ex pleomorphic adenoma, which possesses the characteristics of both carcinoma and sarcoma. In the literature, the number of such cases is very low and the treatment outcomes are varied. Surgery remains the primary local treatment. Radiotherapy may be added to enhance local-regional control. Here, we present a 45-year-old male who underwent surgical removal of pleomorphic adenoma of the right parotid gland twice. He was eventually diagnosed with carcinosarcoma ex pleomorphic adenoma. Treatment consisted of superficial parotidectomy and adjuvant concurrent chemoradiation with weekly cisplatin and a radiation dose of 66 Gy. After 30 weeks of follow-up, no disease recurrence or distant metastasis was observed.

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Available abstract

Pleomorphic adenoma of the parotid gland is the most common tumor of the salivary glands. Although very rare, this tumor can undergo malignant transformation, resulting in carcinosarcoma ex pleomorphic adenoma, which possesses the characteristics of both carcinoma and sarcoma. In the literature, the number of such cases is very low and the treatment outcomes are varied. Surgery remains the primary local treatment. Radiotherapy may be added to enhance local-regional control. Here, we present a 45-year-old male who underwent surgical removal of pleomorphic adenoma of the right parotid gland twice. He was eventually diagnosed with carcinosarcoma ex pleomorphic adenoma. Treatment consisted of superficial parotidectomy and adjuvant concurrent chemoradiation with weekly cisplatin and a radiation dose of 66 Gy. After 30 weeks of follow-up, no disease recurrence or distant metastasis was observed.

Key concepts: Pleomorphic adenoma, Carcinosarcoma, Carcinoma ex pleomorphic adenoma, Parotid gland, Medicine, Radiation therapy, Parotidectomy, Adenoma

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