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2016•The Lancet Global HealthOpen access

Aftershocks of scrub typhus in Nepal – Author's reply

Buddha Basnyat

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Abstract

I agree with Hemant Ojha and Sampanna Jung Rayamajhi that, although the suggestion to use doxycycline for treatment of a presumptive diagnosis of scrub typhus is justified,1 we clearly have to be on the lookout for doxycycline-resistant scrub typhus. Indeed, the Comment was written in an attempt to serve as a wake-up call for more research on both typhus and typhoid, especially regarding reliable, rapid diagnostic tests to distinguish between these kinds of undifferentiated febrile illnesses in the tropics.

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I agree with Hemant Ojha and Sampanna Jung Rayamajhi that, although the suggestion to use doxycycline for treatment of a presumptive diagnosis of scrub typhus is justified,1 we clearly have to be on the lookout for doxycycline-resistant scrub typhus. Indeed, the Comment was written in an attempt to serve as a wake-up call for more research on both typhus and typhoid, especially regarding reliable, rapid diagnostic tests to distinguish between these kinds of undifferentiated febrile illnesses in the tropics.

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Available abstract

I agree with Hemant Ojha and Sampanna Jung Rayamajhi that, although the suggestion to use doxycycline for treatment of a presumptive diagnosis of scrub typhus is justified,1 we clearly have to be on the lookout for doxycycline-resistant scrub typhus. Indeed, the Comment was written in an attempt to serve as a wake-up call for more research on both typhus and typhoid, especially regarding reliable, rapid diagnostic tests to distinguish between these kinds of undifferentiated febrile illnesses in the tropics.

Key concepts: Scrub typhus, Typhoid fever, Orientia tsutsugamushi, Typhus, Dengue fever, Medicine, Doxycycline, Fever of unknown origin

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