A Pharmacokinetic Analysis of a Novel Fixed Dose Oral Combination of Paracetamol and Ibuprofen, with Emphasis on Food Effect

We hereby report the results of a single-dose, open-label, randomized, four-way cross-over pharmacokinetic study to determine and compare the pharmacokinetic parameters of 1000 mg paracetamol and 300 mg ibuprofen, administered orally, either alone or in combination, under fasting and in combination under fed conditions. Methods