2016•Russian Journal of General ChemistryRequires access
Synthesis, single crystal x-ray analysis, and antimicrobial activity of new (22E)-N'-(4-methoxybenzylidene)-2-[3-cyano-7,8-dihydro-4-(5-methylfuran-2-yl)-2-oxo-2H-pyrano[4,3-b]pyridin-1(5H)-yl]acetohydrazide
Abd El‐Galil E. Amr, Sahera F. Mohamed, Mohamed A. Al‐Omar, Hazem A. Ghabbour
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Abstract
(22E)- N '-(4-Methoxybenzylidene)-2-[3-cyano-7,8-dihydro-4-(5-methylfuran-2-yl)-2-oxo-2 H -pyrano[ 4,3- b ]pyridin-1(5 H )-yl]acetohydrazide (2) was synthesized from 2-[3-cyano-7,8-dihydro-4-(5-methylfuran- 2-yl)-2-oxo-2H-pyrano[4,3- b ]pyridin-1(5 H )-yl]acetohydrazide (1) as starting material with 4-methoxybenzaldehyde. The product 2 2 was evaluated for antimicrobial activity against gram positive and gram negative bacteria in comparison with Vebromycine as the standard antibiotics. Compound 2 , C 24 H 22 N 4 O 5 , crystallized as triclinic, P -1, a = 8.3496(5) Å, b = 10.9465(9) Å, c = 12.1495(9) Å, a = 74.694(4)°, β = 84.793(3)°, γ = 84.495 (3)°, V = 1063.64(13) Å 3 , Z = 2.