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2016•Transplantation and Cellular TherapyOpen access

Purtscher-like Retinopathy: A Rare Complication of HSCT-Associated Thrombotic Microangiopathy

Katherine Voigt, P.A. Barragán Castillo, Charlene Crockett, Caridad Martinez, Kathryn Leung, Ghadir Sasa, Robert B. Garoon, Robert A. Krance, Swati Naik

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Abstract

We describe here a case of Purtscher-like retinopathy (PLR) linked with Hematopoietic Stem Cell Transplant (HSCT) associated thrombotic microangiopathy (TA-TMA). TA-TMA causes endothelial damage and results in micro-thrombi in capillaries and arterioles. PLR is associated with micro-thrombi that occlude the retinal arteries and cause retinal injury. This report describes the clinical course for PLR which has similar features to and can mimic hypertensive retinopathy.

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What this paper is about

We describe here a case of Purtscher-like retinopathy (PLR) linked with Hematopoietic Stem Cell Transplant (HSCT) associated thrombotic microangiopathy (TA-TMA). TA-TMA causes endothelial damage and results in micro-thrombi in capillaries and arterioles. PLR is associated with micro-thrombi that occlude the retinal arteries and cause retinal injury. This report describes the clinical course for PLR which has similar features to and can mimic hypertensive retinopathy.

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Available abstract

We describe here a case of Purtscher-like retinopathy (PLR) linked with Hematopoietic Stem Cell Transplant (HSCT) associated thrombotic microangiopathy (TA-TMA). TA-TMA causes endothelial damage and results in micro-thrombi in capillaries and arterioles. PLR is associated with micro-thrombi that occlude the retinal arteries and cause retinal injury. This report describes the clinical course for PLR which has similar features to and can mimic hypertensive retinopathy.

Key concepts: Thrombotic microangiopathy, Medicine, Microangiopathy, Retinopathy, Complication, Retinal, Ophthalmology, Hematopoietic stem cell transplantation

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