1998•Nihon Naika Gakkai ZasshiOpen access

Advances of clinical laboratory for collagen disease. II. Advances of collagen disease test and disease state elucidation. 3. Antinuclear antibody and anti-DNA antibody.

宮脇昌二

Abstract

今日,間接蛍光抗体法による抗核抗体(FANA)の検出は膠原病のスクリーニング法として広く第一線に定着している.しかし近年, FANAの感度が上昇し,健常人を含めた各種疾患に発現しやすくなり, FANAの結果に対する臨床側の慎重な対応が必要となった.またFANAの染色型に関する臨床的解釈にも大きな限界が認められる.個別抗核抗体の中では, SLEの臨床上重視されている抗DNA抗体の検出法に数々の誤解と問題点が存在することを述べた

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Key concepts: Medicine, Anti-nuclear antibody, Collagen disease, Antibody, Disease, Immunology, Pathology, Autoantibody