2008•日本臨床細胞学会雑誌Open access
A case of Rosai-Dorfman disease with typical cytological feature
Hisayuki Tsugitomi, Mitsuo Nakamura, Daisuke Mori, Humirou YAMASAKI, Osamu Tokunaga
Open full text 0 citations
Abstract
We report a case of Rosai-Dorfman disease with typical cytological features of the lymph node confirmed by imprint smear, which showed numerous plasma cells and large histiocytes containing nondegenerated blood cells. Immunohistochemically, histiocytes were positive for S-100 protein. Histologically, follicles were decreased and histiocyte filling was noted in the expanded lymphatic sinus. Emperipolesis was also noted. Rosai-Dorfman disease is diagnosed by the presence of emperipolesis in large histiocytes, considerable plasma cell infiltration, and positive S-100 protein presence in histiocytes confirmed by imprint smear.
Open-access reader