2016•International journal of biophysicsOpen access
The Biophysical Mutation in Genetic Diseases
Ratan Kumar Sarkar
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Abstract
Sickle-cell anemia is caused mutation at molecular point-6 of hemoglobin beta polypeptide chain that would be bisectional significant site shows a deleterious mutation. P53 is a tumor suppresor protein having a curious interaction between molecular point and amino acid composition and is inactivated by several biophysical mutations at its core domain with fall of thermodynamic stability tends to disorder.