2016•EpigenomicsRequires access
An Update on the Epigenetics of Glioblastomas
Wallax Augusto Silva Ferreira, Danilo do Rosário Pinheiro, Carlos Antônio da Costa, Symara Rodrigues-Antunes, Mariana Diniz Araújo, Mariceli Baia Leão Barros, Adriana Teixeira, Thamirys Aline Silva Faro, Rommel Mário Rodríguez Burbano, Edivaldo Herculano Corrêa de Oliveira, Maria Lúcia Harada, Bárbara do Nascimento Borges
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Abstract
Glioblastomas, also known as glioblastoma multiforme (GBM), are the most aggressive and malignant type of primary brain tumor in adults, exhibiting notable variability at the histopathological, genetic and epigenetic levels. Recently, epigenetic alterations have emerged as a common hallmark of many tumors, including GBM. Considering that a deeper understanding of the epigenetic modifications that occur in GBM may increase the knowledge regarding the tumorigenesis, progression and recurrence of this disease, in this review we discuss the recent major advances in GBM epigenetics research involving histone modification, glioblastoma stem cells, DNA methylation, noncoding RNAs expression, including their main alterations and the use of epigenetic therapy as a valid option for GBM treatment.