2016•F1000ResearchOpen access

Eph-ephrin signaling in nervous system development (version 1; referees: 2 approved)

Karina S. Cramer, Ilona J. Miko

Abstract

Ephrins and Eph receptors enable contact-mediated interactions between cells at every stage of nervous system development. In spite of their broad binding affinities, Eph proteins facilitate specificity in neuronal migration and axon targeting. This review focuses on recent studies that demonstrate how these proteins interact with each other, and with other signaling pathways, to guide specificity in a diverse set of developmental processes.

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Key concepts: Erythropoietin-producing hepatocellular (Eph) receptor, Ephrin, Axon guidance, Neuroscience, Nervous system, Biology, Central nervous system, Open peer review