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Verrucous carcinomaoftheanuscontaining human papillomavirus type16DNA detected byinsitu hybridisation: a casereport

Kari Juhani Syrjänen

Abstract

Verrucous carcinoma oftheanusisadistinct and rare variantof well-differentia ted squamouscellcarcinoma. A caseofanal verrucous carcinoma ina35yearoldman was studied bylight microscopy andinsituDNA hybridization. Human papillomavirus (HPV) type16DNA sequences weredemonstrated in thetumourcells, aswellasincells showing koilocytotic and dyskeratotic changes. The possible viral(HPV)aetiology ofverrucous carcinoma isconsidered witha reviewofthe previous literature.

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Key concepts: Verrucous carcinoma, Human papillomavirus, Koilocyte, Etiology, Papillomaviridae, Pathology, Dermatology, Carcinoma