Ribozymes Targeted Against AMLlIMTG8: Evaluation of Ribozyme Efficiency in a Cell-Free System and Transfection with Ca tionic Liposome

It is often found that tumors have chromosomal translocation, especially in hematological malignancies. A specific chromosomal translocation is related to a specific type of disease. Recent studies have revealed that genetic aberrations originated from these chromosomal translocations have a key role in oncogenesis. Formation of a chimeric fusion gene is one such genetic aberration. Because chimeric fusion genes are expressed specifically in tumor cells and participate in oncogenesis, specific gene inhibition of the chimeric fusion genes is thought to be a good approach for treatment. These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.