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2011•touchREVIEWS in Oncology & HaematologyRequires access

Positron-emission Tomography Imaging in Breast Cancer

William B. Eubank, Jean H. Lee, David A. Mankoff, Associate Professor of Radiology, Puget Sound VA Health Care System, Assistant Professor of Radiology

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Abstract

There are four major diagnostic tasks in breast cancer: detection and diagnosis; staging (locoregional and distant metastases); response to treatment (neoadjuvant and metastatic therapy); and characterization of the individual tumor for selection of the most appropriate therapy. The use of fluorodeoxyglucose (FDG) positron-emission tomography (PET) and PET–computed tomography (PET-CT) in all four of these tasks has been investigated. The aim of this article is to discuss the strengths and weaknesses of FDG PET with regard to each of these tasks. The diagnostic areas for which FDG PET appears most suited for clinical decision-making will be highlighted.

About this research paper

What this paper is about

There are four major diagnostic tasks in breast cancer: detection and diagnosis; staging (locoregional and distant metastases); response to treatment (neoadjuvant and metastatic therapy); and characterization of the individual tumor for selection of the most appropriate therapy. The use of fluorodeoxyglucose (FDG) positron-emission tomography (PET) and PET–computed tomography (PET-CT) in all four of these tasks has been investigated. The aim of this article is to discuss the strengths and weaknesses of FDG PET with regard to each of these tasks. The diagnostic areas for which FDG PET appears most suited for clinical decision-making will be highlighted.

Why it matters

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Key contribution

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Available abstract

There are four major diagnostic tasks in breast cancer: detection and diagnosis; staging (locoregional and distant metastases); response to treatment (neoadjuvant and metastatic therapy); and characterization of the individual tumor for selection of the most appropriate therapy. The use of fluorodeoxyglucose (FDG) positron-emission tomography (PET) and PET–computed tomography (PET-CT) in all four of these tasks has been investigated. The aim of this article is to discuss the strengths and weaknesses of FDG PET with regard to each of these tasks. The diagnostic areas for which FDG PET appears most suited for clinical decision-making will be highlighted.

Key concepts: Positron emission tomography, Medicine, Breast cancer, Radiology, Medical physics, Cancer, Positron Emission Tomography-Computed Tomography, Positron emission

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