Formulation And Evaluation Of Bilayered Tablets OfHp-Β- Cyclodextrin Complexed Glimepiride With Metformin Hydrochloride For Immediate And Sustain Release

The aim of present study is to formulate and evaluate the bilayered tablets containing immediate release layer of HP�β�Cycloextrin inclusi on complexed Glimepiride to produce immediate therapeutic effect and sustained release layer containing Metformin Hcl by using HPMC as release retardant. Glimepiride act by stimulating the release of insulin from functioning pancreatic beta cells. Metformin hydrochloride helps to suppress appetite and diminishes hepatic glucose excretion, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. It doesn’t stimulate insulin release and the combination of these two drugs is more effective than single drug therapy to treat NIDDM (Non insulin dependent Diabetes mellitus). The reason for Bi� layer tablet formulation is to separate physically or chemically incompatible ingredients and to produce repeat action or prolonged action tablet. Total seven trial batches have been manufactured to optimize and develop a robust and stable formulation, both wet & dry granulation processes were used for formulation. The compressed tablets were evaluated for