2016•Unpublished venueRequires access
Short Communication : Possible Association of N ewly Absorbed Serotonin With Nonmetabolic, Granule-located Adenine Nucleotides in
Holm Holmsen, Carol A. Setkowsky, H. James Day
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Abstract
[3H]-adenine-Iabeled human platelets in same in both systems. This shows that plasma were incubated with or without when serotonin is taken up by human nonradioactive serotonin. Release reaction platelets, it enters the compartment conwas then induced by ADP, epinephrine, taming nonmetabolic, granula-stored ATP, collagen, or thrombin. Platelets that had and not the compartment with metabolic been incubated with serotonin released extragranular ATP. These results suggest four times asmuch serotoninas platelets that the mechanism of serotonin storage incubated without serotonin. The specific in human platelets is similar to that in radioactivities of the ATPand ADP re- other species investigated, i.e., rabbit, leased to plasma during release reaction guinea pig, and pig. induced with all four inducers were the