2.1.3 With Isocyanide Participation

Abstract Isocyanide-based multicomponent reactions represent a very important synthetic method for the synthesis of heterocyclic compounds with potential biological and medicinal activities. The nucleophilic property of isocyanides makes them a popular reactant class for the development of novel multicomponent reactions. One of the isocyanide-based multicomponent reaction approaches involves the generation of a dipolar intermediate by the addition of isocyanides to electron-deficient α, β-unsaturated carbonyl compounds such as dialkyl acetylenedicarboxylates; the dipolar intermediate can then be captured efficiently by various dipolarophiles such as CH-, NH-, and OH-acids, electron-deficient alkenes, and imines to form diverse cycloadducts.