Radioimmunoassay of tricyclic antidepressants

The tricyclic antidepressant drugs (TCA) are widely used in the treatment of depression. Since there are marked interindividual differences in the steady state concentrations of a TCA in plasma, the monitoring of the plasma concentrations as a guide to effective dosage has been developed. There are indications that both high and low concentrations of nortriptyline (NT), for example, are associated with poor clinical responses (Åsberg, 1974; Kragh-Sørensen et al. , 1976), while the response may increase linearly with the plasma concentrations of imipramine and amitriptyline (AMI) (Gram, 1980). These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.