2016Journal of Microbiology Immunology and InfectionOpen access

MgrB variants in colistin-susceptible and colistin-resistant Klebsiella pneumoniae ST258

Béla Kocsis, Béla Kádár, Ákos Tóth, Alexandra Fullár, Dóra Szabó

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Abstract

Resistance determinants of a colistin susceptible and five colistin resistant Klebsiella pneumoniae ST258 from a Hungarian outbreak were investigated. A novel MgrB variant in colistin susceptible strain was found. Elevated phoP and arn gene expressions and wild-type PmrB in all colistin resistant K. pneumoniae were detected. All strains lacked mcr-1.

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Resistance determinants of a colistin susceptible and five colistin resistant Klebsiella pneumoniae ST258 from a Hungarian outbreak were investigated. A novel MgrB variant in colistin susceptible strain was found. Elevated phoP and arn gene expressions and wild-type PmrB in all colistin resistant K. pneumoniae were detected. All strains lacked mcr-1.

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Available abstract

Resistance determinants of a colistin susceptible and five colistin resistant Klebsiella pneumoniae ST258 from a Hungarian outbreak were investigated. A novel MgrB variant in colistin susceptible strain was found. Elevated phoP and arn gene expressions and wild-type PmrB in all colistin resistant K. pneumoniae were detected. All strains lacked mcr-1.

Key concepts: Klebsiella pneumoniae, Colistin, Microbiology, Outbreak, Strain (injury), Biology, Gene, Virology

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