2016•Bioorganic & Medicinal ChemistryOpen access

3-Arylpropionylhydroxamic acid derivatives as Helicobacter pylori urease inhibitors: Synthesis, molecular docking and biological evaluation

Wei-Kang Shi, Rui-Cheng Deng, Pengfei Wang, Qin-Qin Yue, Qi Liu, Kun-Ling Ding, Mei‐Hui Yang, Hongyu Zhang, Si-Hua Gong, Min Deng, Wen-Run Liu, Qiu-Ju Feng, Zhu‐Ping Xiao, Hai‐Liang Zhu

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Key concepts: Urease, Helicobacter pylori, Chemistry, Uncompetitive inhibitor, IC50, Docking (animal), Non-competitive inhibition, Enzyme