ScholarLens Back to search
1965•OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)Open access

The course of lysine hydroxylation during collagen biosynthesis

Edwin A. Popenoe, Robert B. Aronson, Donald D. Van Slyke

Open full text 0 citations

Abstract

Lysine is the obligatory precursor of the 5-hydroxylysine of collagen in rats and presumably in other species. Hydroxylysine, either fed or injected, is not incorporated into collagen. It seems probably that lysine is hydroxyated as a bound amino acid during the course of collagen synthesis. The biochemical mechanism of the introduction of the hydroxyl group onto the number 5 carbon atom of lysine has been studied recently, using lysine labeled with tritium in specific positions.

About this research paper

What this paper is about

Lysine is the obligatory precursor of the 5-hydroxylysine of collagen in rats and presumably in other species. Hydroxylysine, either fed or injected, is not incorporated into collagen. It seems probably that lysine is hydroxyated as a bound amino acid during the course of collagen synthesis. The biochemical mechanism of the introduction of the hydroxyl group onto the number 5 carbon atom of lysine has been studied recently, using lysine labeled with tritium in specific positions.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Lysine is the obligatory precursor of the 5-hydroxylysine of collagen in rats and presumably in other species. Hydroxylysine, either fed or injected, is not incorporated into collagen. It seems probably that lysine is hydroxyated as a bound amino acid during the course of collagen synthesis. The biochemical mechanism of the introduction of the hydroxyl group onto the number 5 carbon atom of lysine has been studied recently, using lysine labeled with tritium in specific positions.

Key concepts: Hydroxylysine, Lysine, Hydroxylation, Chemistry, Biochemistry, Biosynthesis, Amino acid, Hydroxyproline

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
The course of lysine hydroxylation during collagen biosynthesis — Research Paper | ScholarLens