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An Invitro Evaluation Of Cytotoxic Activity Of Sophora Interrupta

T. Vithya, K. Alhasjajiju, B.Rajkapoor And B.K.Savitha

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Abstract

In this study we evaluated the cytotoxicity activity of Sophora interrupta. For evaluation HeLa and HePG2 cell lines were treated with the various concentrations of Methanolic extract. The result showed an IC50 value of 211.5$g/ml and158.2$g/ml respectively in HeLa and HePG2 cell lines. The MTT assay results confirmed the cytotoxicity of the plant. Further, molecular characterisation studies and in vivo studies recommended to confirm still the anticancer activity of this plant.

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What this paper is about

In this study we evaluated the cytotoxicity activity of Sophora interrupta. For evaluation HeLa and HePG2 cell lines were treated with the various concentrations of Methanolic extract. The result showed an IC50 value of 211.5$g/ml and158.2$g/ml respectively in HeLa and HePG2 cell lines. The MTT assay results confirmed the cytotoxicity of the plant. Further, molecular characterisation studies and in vivo studies recommended to confirm still the anticancer activity of this plant.

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Available abstract

In this study we evaluated the cytotoxicity activity of Sophora interrupta. For evaluation HeLa and HePG2 cell lines were treated with the various concentrations of Methanolic extract. The result showed an IC50 value of 211.5$g/ml and158.2$g/ml respectively in HeLa and HePG2 cell lines. The MTT assay results confirmed the cytotoxicity of the plant. Further, molecular characterisation studies and in vivo studies recommended to confirm still the anticancer activity of this plant.

Key concepts: HeLa, Cytotoxicity, In vivo, Sophora, MTT assay, Cytotoxic T cell, In vitro, IC50

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