2016•Drug Metabolism and DispositionRequires access

The Use of In Vitro Data and Physiologically-Based Pharmacokinetic Modeling to Predict Drug Metabolite Exposure: Desipramine Exposure in Cytochrome P4502D6 Extensive and Poor Metabolizers Following Administration of Imipramine

Huy Quang Nguyen, Ernesto Callegari, R. Scott Obach

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Key concepts: Desipramine, Imipramine, Metabolite, Pharmacology, Physiologically based pharmacokinetic modelling, Pharmacokinetics, Active metabolite, CYP2D6

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The Use of In Vitro Data and Physiologically-Based Pharmacokinetic Modeling to Predict Drug Metabolite Exposure: Desipramine Exposure in Cytochrome P4502D6 Extensive and Poor Metabolizers Following Administration of Imipramine — Research Paper | ScholarLens