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2003•Humana Press eBooksRequires access

Caged Intracellular Messengers and the Inositol Phosphate Signaling Pathway

Ian Parker

Open publisher page 5 citations

Abstract

The development of caged intracellular messenger compounds offers an elegant new approach to quantitative, time-resolved studies of intracellular signaling pathways. Several reviews of caged compounds have recently appeared (; ; ; ), which may be consulted for details of their synthesis, properties, and use. The present chapter concentrates on practical aspects of the use of caged compounds, derived from work in the author’s laboratory using caged inositol trisphosphate to study signaling in Xenopus oocytes.

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What this paper is about

The development of caged intracellular messenger compounds offers an elegant new approach to quantitative, time-resolved studies of intracellular signaling pathways. Several reviews of caged compounds have recently appeared (; ; ; ), which may be consulted for details of their synthesis, properties, and use. The present chapter concentrates on practical aspects of the use of caged compounds, derived from work in the author’s laboratory using caged inositol trisphosphate to study signaling in Xenopus oocytes.

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Available abstract

The development of caged intracellular messenger compounds offers an elegant new approach to quantitative, time-resolved studies of intracellular signaling pathways. Several reviews of caged compounds have recently appeared (; ; ; ), which may be consulted for details of their synthesis, properties, and use. The present chapter concentrates on practical aspects of the use of caged compounds, derived from work in the author’s laboratory using caged inositol trisphosphate to study signaling in Xenopus oocytes.

Key concepts: Second messenger system, Intracellular, Inositol, Xenopus, Inositol phosphate, Signal transduction, Chemistry, Cell biology

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