ScholarLens Back to search
2003•ACS symposium seriesRequires access

Divergent Cytotoxic Effects of Conjugated Linoleic Acid Isomers on NCI-N87 Cells

Sook J. Park, Cherl W. Park, Seck J. Kim, Jung K. Kim, Young R. Kim, Young Seo Kim, Yeong Lae Ha

Open publisher page 8 citations

Abstract

Cytotoxic effects of four conjugated linoleic acid (CLA) isomers ( trans -10, cis -12 CLA; cis -9, trans -11 CLA; trans -10, trans -12 CLA; and trans -9, trans -11 CLA) were evaluated in NCI-N87 gastric cancer cells. NCI-N87 cells were incubated in serum-free medium with 20 µM CLA isomers and linoleic acid over a period of 6 days. All CLA isomers inhibited the proliferation of the cells, however, linoleic acid did not. Efficacy of trans -9, trans -11 CLA in inhibiting the cell proliferation was similar to that of trans -10, trans -12 CLA and was much higher than that of trans -10, cis -12 CLA or cis -9, trans -11 CLA. These results indicate that cytotoxicity of trans -9, trans -11 and trans -10, trans -12 CLA (designated trans/trans CLA) isomers for NCI-N87 cells was stronger than that of their corresponding cis -9, trans -11 CLA or trans -10, cis -12 CLA (designated cis/trans CLA) isomers.

About this research paper

What this paper is about

Cytotoxic effects of four conjugated linoleic acid (CLA) isomers ( trans -10, cis -12 CLA; cis -9, trans -11 CLA; trans -10, trans -12 CLA; and trans -9, trans -11 CLA) were evaluated in NCI-N87 gastric cancer cells. NCI-N87 cells were incubated in serum-free medium with 20 µM CLA isomers and linoleic acid over a period of 6 days. All CLA isomers inhibited the proliferation of the cells, however, linoleic acid did not. Efficacy of trans -9, trans -11 CLA in inhibiting the cell proliferation was similar to that of trans -10, trans -12 CLA and was much higher than that of trans -10, cis -12 CLA or cis -9, trans -11 CLA. These results indicate that cytotoxicity of trans -9, trans -11 and trans -10, trans -12 CLA (designated trans/trans CLA) isomers for NCI-N87 cells was stronger than that of their corresponding cis -9, trans -11 CLA or trans -10, cis -12 CLA (designated cis/trans CLA) isomers.

Why it matters

OpenAlex reports 8 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Cytotoxic effects of four conjugated linoleic acid (CLA) isomers ( trans -10, cis -12 CLA; cis -9, trans -11 CLA; trans -10, trans -12 CLA; and trans -9, trans -11 CLA) were evaluated in NCI-N87 gastric cancer cells. NCI-N87 cells were incubated in serum-free medium with 20 µM CLA isomers and linoleic acid over a period of 6 days. All CLA isomers inhibited the proliferation of the cells, however, linoleic acid did not. Efficacy of trans -9, trans -11 CLA in inhibiting the cell proliferation was similar to that of trans -10, trans -12 CLA and was much higher than that of trans -10, cis -12 CLA or cis -9, trans -11 CLA. These results indicate that cytotoxicity of trans -9, trans -11 and trans -10, trans -12 CLA (designated trans/trans CLA) isomers for NCI-N87 cells was stronger than that of their corresponding cis -9, trans -11 CLA or trans -10, cis -12 CLA (designated cis/trans CLA) isomers.

Key concepts: Conjugated linoleic acid, Cis–trans isomerism, Linoleic acid, Chemistry, Cytotoxic T cell, Cytotoxicity, Stereochemistry, Biochemistry

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Divergent Cytotoxic Effects of Conjugated Linoleic Acid Isomers on NCI-N87 Cells — Research Paper | ScholarLens