Peripheral Blood Hematopoietic Stem-cell Mobilization for Autologous Transplantation

Autologous hematopoietic stem-cell transplantation is important in the treatment of several lymphohematopoietic malignancies. Procurement of adequate stem cells, for which CD34 positivity serves as a useful surrogate, is necessary prior to the procedure. Several methods of mobilization are widely used, but methods for individual patients should depend on their specific clinical situation. More than 20% of patients do not achieve adequate mobilization and those who require numerous aphereses to accomplish adequate CD34+ cell yield may experience delayed hematopoietic recovery.