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Clippen gelijkwaardig aan coiling bij hersenaneurysma

Nicolaas A. Bakker, Nic J.G.M. Veeger, J. Marc C. van Dijk

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Abstract

The 10-year follow-up results of the International Subarachnoid Aneurysm Trial essentially show the same results as the 5-year follow-up: no significant differences between endovascular coiling and neurosurgical clipping of ruptured intracranial aneurysms in terms of functional outcome (primary endpoint). The authors' statement that cumulative mortality rates still favour coiling did not hold up after modified intention-to-treat analysis had been performed. Moreover, the authors themselves show that survival between these treatment options is not significantly different. In the long term, coiling and clipping should therefore both be regarded viable treatment options.

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What this paper is about

The 10-year follow-up results of the International Subarachnoid Aneurysm Trial essentially show the same results as the 5-year follow-up: no significant differences between endovascular coiling and neurosurgical clipping of ruptured intracranial aneurysms in terms of functional outcome (primary endpoint). The authors' statement that cumulative mortality rates still favour coiling did not hold up after modified intention-to-treat analysis had been performed. Moreover, the authors themselves show that survival between these treatment options is not significantly different. In the long term, coiling and clipping should therefore both be regarded viable treatment options.

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Available abstract

The 10-year follow-up results of the International Subarachnoid Aneurysm Trial essentially show the same results as the 5-year follow-up: no significant differences between endovascular coiling and neurosurgical clipping of ruptured intracranial aneurysms in terms of functional outcome (primary endpoint). The authors' statement that cumulative mortality rates still favour coiling did not hold up after modified intention-to-treat analysis had been performed. Moreover, the authors themselves show that survival between these treatment options is not significantly different. In the long term, coiling and clipping should therefore both be regarded viable treatment options.

Key concepts: Medicine, Clipping (morphology), Endovascular coiling, Subarachnoid hemorrhage, Clinical endpoint, Surgery, Aneurysm, Randomized controlled trial

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