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2016•Journal of Neural EngineeringRequires access

Vagus nerve stimulation: state of the art of stimulation and recording strategies to address autonomic function neuromodulation

David Guiraud, David Andreu, Stéphane Bonnet, Guy Carrault, Pascal Couderc, Albert Alain Hagège, Christine A. Henry, Alfredo I. Hernandez, Nicole Karam, Virginie Le Rolle, Philippe Mabo, Paweł Maciejasz, Charles‐Henri Malbert, Éloi Marijon, S. Maubert, Chloé A. Picq, Olivier Rossel, Jean-Luc Bonnet

Open publisher page 91 citations

Abstract

OBJECTIVE: Neural signals along the vagus nerve (VN) drive many somatic and autonomic functions. The clinical interest of VN stimulation (VNS) is thus potentially huge and has already been demonstrated in epilepsy. However, side effects are often elicited, in addition to the targeted neuromodulation. APPROACH: This review examines the state of the art of VNS applied to two emerging modulations of autonomic function: heart failure and obesity, especially morbid obesity. MAIN RESULTS: We report that VNS may benefit from improved stimulation delivery using very advanced technologies. However, most of the results from fundamental animal studies still need to be demonstrated in humans.

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What this paper is about

OBJECTIVE: Neural signals along the vagus nerve (VN) drive many somatic and autonomic functions. The clinical interest of VN stimulation (VNS) is thus potentially huge and has already been demonstrated in epilepsy. However, side effects are often elicited, in addition to the targeted neuromodulation. APPROACH: This review examines the state of the art of VNS applied to two emerging modulations of autonomic function: heart failure and obesity, especially morbid obesity. MAIN RESULTS: We report that VNS may benefit from improved stimulation delivery using very advanced technologies. However, most of the results from fundamental animal studies still need to be demonstrated in humans.

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OpenAlex reports 91 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

OBJECTIVE: Neural signals along the vagus nerve (VN) drive many somatic and autonomic functions. The clinical interest of VN stimulation (VNS) is thus potentially huge and has already been demonstrated in epilepsy. However, side effects are often elicited, in addition to the targeted neuromodulation. APPROACH: This review examines the state of the art of VNS applied to two emerging modulations of autonomic function: heart failure and obesity, especially morbid obesity. MAIN RESULTS: We report that VNS may benefit from improved stimulation delivery using very advanced technologies. However, most of the results from fundamental animal studies still need to be demonstrated in humans.

Key concepts: Neuromodulation, Vagus nerve stimulation, Stimulation, Neuroscience, Autonomic function, Medicine, Vagus nerve, Computer science

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