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[Analysis of CD8(+) and CD8(+)CD28(-) cell subsets in patients with hepatocellular carcinoma].

Yu‐Rong Qiu, Chunli Yang, Lian-Bo Chen, Qian Wang

Open publisher page 6 citations

Abstract

OBJECTIVE: To study the expression of the costimulatory molecule CD28 on peripheral blood CD8(+)T cells from patients with hepatocellular carcinoma (HCC). METHOD: The expression of CD28 on CD8(+), CD8(+)CD28(-)- and CD8(+)CD28(+) cell subsets in the peripheral blood obtained from 20 HCC patients and 15 healthy controls were assayed by flow cytometry. RESULTS: The elevated percentages of CD8(+) cells, decreased percentages of CD8(+)CD28(+) cells and increased percentages of CD8(+)CD28(-)- cells were observed in the peripheral blood of HCC patients as compared with those of the control group (P<0.01). Positive correlation between the percentage of CD8(+)CD28(-)- cells and that of CD8(+) cells were found. CONCLUSION: CD28 expression on CD8(+) T cells was aberrant in the peripheral blood of HCC patients, and the elevation of CD8(+)CD28(-)- cell number results in the increase of CD8(+) cell number.

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What this paper is about

OBJECTIVE: To study the expression of the costimulatory molecule CD28 on peripheral blood CD8(+)T cells from patients with hepatocellular carcinoma (HCC). METHOD: The expression of CD28 on CD8(+), CD8(+)CD28(-)- and CD8(+)CD28(+) cell subsets in the peripheral blood obtained from 20 HCC patients and 15 healthy controls were assayed by flow cytometry. RESULTS: The elevated percentages of CD8(+) cells, decreased percentages of CD8(+)CD28(+) cells and increased percentages of CD8(+)CD28(-)- cells were observed in the peripheral blood of HCC patients as compared with those of the control group (P<0.01). Positive correlation between the percentage of CD8(+)CD28(-)- cells and that of CD8(+) cells were found. CONCLUSION: CD28 expression on CD8(+) T cells was aberrant in the peripheral blood of HCC patients, and the elevation of CD8(+)CD28(-)- cell number results in the increase of CD8(+) cell number.

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Available abstract

OBJECTIVE: To study the expression of the costimulatory molecule CD28 on peripheral blood CD8(+)T cells from patients with hepatocellular carcinoma (HCC). METHOD: The expression of CD28 on CD8(+), CD8(+)CD28(-)- and CD8(+)CD28(+) cell subsets in the peripheral blood obtained from 20 HCC patients and 15 healthy controls were assayed by flow cytometry. RESULTS: The elevated percentages of CD8(+) cells, decreased percentages of CD8(+)CD28(+) cells and increased percentages of CD8(+)CD28(-)- cells were observed in the peripheral blood of HCC patients as compared with those of the control group (P<0.01). Positive correlation between the percentage of CD8(+)CD28(-)- cells and that of CD8(+) cells were found. CONCLUSION: CD28 expression on CD8(+) T cells was aberrant in the peripheral blood of HCC patients, and the elevation of CD8(+)CD28(-)- cell number results in the increase of CD8(+) cell number.

Key concepts: CD28, CD8, Flow cytometry, Cytotoxic T cell, Hepatocellular carcinoma, Biology, Medicine, Immunology

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[Analysis of CD8(+) and CD8(+)CD28(-) cell subsets in patients with hepatocellular carcinoma]. — Research Paper | ScholarLens