A comparison of clomipramine and doxepin in neurotic depression.

Results of a double-blind 4-week trial in depressed outpatients given clomipramine (N = 30) or doxepin (N = 36) are reported. Both groups showed significant improvement in physician-rated measures after 1 week of treatment; comparison of the groups favored clomipramine over doxepin for four of six measures. The response to treatment was less clear-cut with the patient-rated measures. The overall incidence and severity of adverse experiences were similar for both treatment groups. Clomipramine was effective, safe, and well tolerated as compared to doxepin in the treatment of outpatients with neurotic depression.