2015•Unpublished venueRequires access

Downregulation of Vascular Endothelial Growth FactorEnhances Chemosensitivity by Induction of Apoptosisin Hepatocellular Carcinoma Cells

Đoàn Chính Chung, Lê Thành Long, Hoàng Nghĩa Sơn, Le Bao, Do Minh Si, Le Van Dong

Abstract

Objective Hepatocellular carcinoma (HCC), one of the most common cancers worldwide, is resistant to anticancer drugs. Angiogenesis is a major cause of tumor resistance to chemotherapy, and vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis. The purpose of this study is to investigate the impact of small-interfering RNA targeting VEGF gene (VEGF-siRNA) on chemosensitivity of HCC cells in vitro.

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Key concepts: Angiogenesis, Hepatocellular carcinoma, Vascular endothelial growth factor, Cancer research, Small interfering RNA, Downregulation and upregulation, Regulator, VEGF receptors