1996•PubMedRequires access
Synthesis and biological activity of a conformationally constrained chemotactic gamma-lactam formyl tetrapeptide.
Giorgio Cavicchioni, Angela Breveglieri, Eva Reali, Susanna Spisani
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Abstract
The synthesis and biological activity on human neutrophils of for-Met-(gamma-lactam)-Leu-Phe-OMe [fM(gamma l)LP-OMe], an analogue of the chemotactic fMLP-OMe, are reported. The tetrapeptide evidences chemotactic activity as well as superoxide anion production and lysozyme release, although with lower efficacy when compared with the parent tripeptide.