1997•PubMedRequires access

[Neoplasm-inhibiting effect and sensitivity-promoting effect of indomethacin in vitro].

G Zhang, Chunyan Duan, J Shi, Ai‐min Leng

Abstract

OBJECTIVE: To explore an anti-tumor effect of indomethacin on human colon adenocarcinoma cell line HCT116, and its mechanism. METHODS: MTT, agarose gel electrophoresis, TdT and flow cytometry were used to study cell proliferation and apoptosis. RESULTS: Indomethacin significantly inhibited the proliferation of HCT116 cells and induced apoptosis with a "dose-time" dependent pattern. A synergic effect of inhibiting cancer cells proliferation was observed when combined with 5-Fu. CONCLUSION: Inhibition of proliferation and induction of apoptosis contribute to the mechanisms for anti-tumor activity of indomethacin.

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Key concepts: Apoptosis, Flow cytometry, Cell growth, Agarose gel electrophoresis, In vitro, MTT assay, Chemistry, Cancer research