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1972•Clinical Pharmacology & TherapeuticsRequires access

Effect of aspirin, caffeine, and codeine on the metabolism of phenacetin and acetaminophen

Barry H. Thomas, Blake B. Coldwell, W. Zeitz, G. Solomonraj

Open publisher page 25 citations

Abstract

The metabolism of phenacetin (P) and acetaminophen (A') alone and with aspirin (A), caffeine (C), and codeine (C') (APCC' and AA'CC') was studied in 24 human volunteers. The principle route of phenacetin metabolism and the total obsorption of phenacetin were not affected by the drug combination. The proportion of the dose of phenacetin metabolized to 2‐hydl'Oxyphenetidine (2‐0HP) was increased from 1.9 to 3.4 per cent when APCC' was ingested. Large individual variations in the amounts of 2‐0HP excreted were observed. The changes produced in the metabolism of acetaminophen when it was taken as AA'CC' were minor. No 2‐0HP was detected after administration of acetaminophen. No changes in blood and urine were observed with any of the drug treatments.

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What this paper is about

The metabolism of phenacetin (P) and acetaminophen (A') alone and with aspirin (A), caffeine (C), and codeine (C') (APCC' and AA'CC') was studied in 24 human volunteers. The principle route of phenacetin metabolism and the total obsorption of phenacetin were not affected by the drug combination. The proportion of the dose of phenacetin metabolized to 2‐hydl'Oxyphenetidine (2‐0HP) was increased from 1.9 to 3.4 per cent when APCC' was ingested. Large individual variations in the amounts of 2‐0HP excreted were observed. The changes produced in the metabolism of acetaminophen when it was taken as AA'CC' were minor. No 2‐0HP was detected after administration of acetaminophen. No changes in blood and urine were observed with any of the drug treatments.

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Available abstract

The metabolism of phenacetin (P) and acetaminophen (A') alone and with aspirin (A), caffeine (C), and codeine (C') (APCC' and AA'CC') was studied in 24 human volunteers. The principle route of phenacetin metabolism and the total obsorption of phenacetin were not affected by the drug combination. The proportion of the dose of phenacetin metabolized to 2‐hydl'Oxyphenetidine (2‐0HP) was increased from 1.9 to 3.4 per cent when APCC' was ingested. Large individual variations in the amounts of 2‐0HP excreted were observed. The changes produced in the metabolism of acetaminophen when it was taken as AA'CC' were minor. No 2‐0HP was detected after administration of acetaminophen. No changes in blood and urine were observed with any of the drug treatments.

Key concepts: Phenacetin, Acetaminophen, Codeine, Caffeine, Aspirin, Urine, Metabolism, Pharmacology

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Effect of aspirin, caffeine, and codeine on the metabolism of phenacetin and acetaminophen — Research Paper | ScholarLens